Table 2.

Association results of unconditional analysis and analysis conditional on known Mendelian and functional lipid SNPs in loci where the functional SNPs explain the genome-wide association.

Locus	CHR	Trait	Lead-SNP in the unconditional analysis
			rsID	MAF	Unconditional		Conditional
					Effect (SE)	p-value N	Covariate SNPs in the model (MAF)	Effect (SE)	p-value N
CELSR2-SORT1	1	LDL-C	rs646776	0.216	0.159 (0.015)	1.31×10−25 12739	rs12740374 (21.6 %)	0.001 (0.015)	0.958 12739
		TC	rs646776	0.216	0.123 (0.015)	4.06×10−16 12834	rs12740374 (21.6 %)	0.001 (0.015)	0.959 12834
GCKR	2	TG	rs1260326	0.353	0.128 (0.013)	8.44×10−23 12815	rs1260326 (35.3 %)	NA	NA
LIPC	15	TC	rs1800588	0.251	0.090 (0.015)	7.23×10−10 12825	rs113298164 (1.4 %) rs1800588 (25.1 %)	−2×10−6 (0.015)	1.000 11893
		TG	rs686958	0.252	0.085 (0.015)	6.86×10−9 12801	rs113298164 (1.4 %) rs1800588 (25.1 %)	0.022 (0.015)	0.152 11873
APOE	19	LDL-C	rs7412	0.048	0.648 (0.031)	5.93×10−95 12730	rs7412 (4.8 %) rs429358 (18.1 %)	NA	NA
		TC	rs7412	0.048	0.456 (0.031)	3.10×10−49 12827	rs7412 (4.8 %) rs429358 (18.1 %)	NA	NA
		TG	rs483082	0.229	0.089 (0.015)	5.74×10−9 12799	rs7412 (4.8 %) rs429358 (18.1 %)	NA	NA

The table shows results for unconditional association analysis and analysis conditional on variants known to cause Mendelian forms of dyslipidemic syndromes and, more broadly, variants with known functional impact on lipids (FL SNPs). In case multiple candidate variants were observed in a locus, they were all included in the same model. Results for the lead-SNP from the unconditional analysis are presented from the meta-analysis of Finnish subset (N = 12,834). Effect sizes are presented in s.d units. CHR: Chromosome, MAF: Minor allele frequency, SE: Standard error of effect estimate, N: Number of samples, HDL-C: High-density lipoprotein cholesterol, LDL-C: Low-density lipoprotein cholesterol, TC: Total cholesterol, TG: Triglycerides.