Figure 10.

MAR1 post-treatment significantly improves behavioral outcome after TBI. Three hours after surgery, TBI mice show significant behavioral impairment compared to sham mice in left hindlimb parameters such as stance–swing ratio, percentage swing in stride, and percentage stance in stride (A–C). Data are presented as values of postinjury–preinjury ratios. Post-TBI administration of MAR1 significantly improves behavioral outcome compared to IgG-treated mice in these parameters (D–F). MAR1 and IgG-treated values are presented as fold-change to TBI. Data represent mean± SEM; *p<0.05, n=10 animals per group.