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. 2016 Feb 18;3(1):ENEURO.0128-15.2016. doi: 10.1523/ENEURO.0128-15.2016

Figure 11.

Figure 11.

Blocking type-1 IFN signaling in hematopoietic cells engenders protection following TBI. A, MRI T2 images from bone marrow chimeric mice showing TBI lesion 24 h after injury. WT&cenveo_unknown_entity_wingdings_F0E0;WT mice represent C57BL/6 CD45.1 mice irradiated to abolish hematopoietic cells and reconstituted with BL/6 bone marrow. IFNAR1−/−&cenveo_unknown_entity_wingdings_F0E0;WT mice represent irradiated C57BL/6 CD45.1 mice reconstituted with IFNAR1−/− bone marrow. WT&cenveo_unknown_entity_wingdings_F0E0;IFNAR1−/− mice represent irradiated IFNAR1−/− mice reconstituted with C57BL/6 CD45.1 bone marrow. Scale bar, 1 mm. B, MRI T2 images from chimeric mice showing TBI lesion 7 d after injury. C, IFNAR1−/−&cenveo_unknown_entity_wingdings_F0E0;WT mice have significantly reduced infarct volumes 7 d after injury. Data represent mean± SEM; **p<0.01, n=6–8 animals per group.