Figure 4. Vessel diameters are similar in the periphery and core of tumours.

(a) Marking dye was applied following surgical resection to identify the imaged surface of tumour. Measurements of core (>200 μm from surface) and peripheral (<200 μm from surface) tumour blood vessels was performed on formalin-fixed tumour samples stained using haematoxylin and anti-CD31 mAb. Bar is 100 μm. (b) Comparison of tumour vessel diameters per field (minimum 5 fields) in the periphery (P) versus core (C) in humans and mice, NS, non significant (unpaired Student's t-test). n=3 for patients; n=5 for mice. Data is mean±s.e.m.