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In vivo drug efficacy testing of combination therapy using PDX models. Combination effects of BCL2L1 inhibitor (ABT-737) and cytotoxic drug (irinotecan) were tested in BCL2L1-amplified (11 copies) gastric cancer PDX models. Average tumor sizes of treated groups are plotted (left panel) and representative tumors after treatment are shown (right panel). Scale bar: 10 mm. (reproduced from Park et al., 2015).
