Figure 4. EGCG induces H3 hypo-acetylation as a result of HAT/HDAC binding exchange.
The H3 acetylation was enhanced by PCB 126 and decreased by the pre-treatment with EGCG in the NF-κB-regulated genes. H3 is the control for nucleosomal occupancy. Values are means ± SD with n=3. *Significantly increased compared to the DMSO control. ^Significantly decreased compared to the DMSO control. #Significantly decreased compared to the PCB treatment group.