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. Author manuscript; available in PMC: 2016 Feb 18.
Published in final edited form as: J Mol Biol. 2014 Jul 30;427(1):106–120. doi: 10.1016/j.jmb.2014.07.026

Figure 5. Combined NBD1 stabilizing mutations promote maturation and function of R1070W CFTR in both ΔF508 and wild-type backgrounds.

Figure 5

(a). Single channel current tracings of the wild type, ΔF508/Combo and ΔF508/Combo/R1070W CFTRs at 25°C. All points histograms, single channel conductances, and open probailities are shown as in Fig. 4. (b) Single channel currents at 37°C showing the influence of combined NBD1 stabilizing changes on ΔF508 and wild-type CFTR without and with the R1070W mutation. X-scale bar below traces is 10s.