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. Author manuscript; available in PMC: 2016 Feb 18.
Published in final edited form as: J Mol Biol. 2014 Jul 30;427(1):106–120. doi: 10.1016/j.jmb.2014.07.026

Figure 6. Combined NBD1 stabilizing mutations and R1070W result in phosphorylation-independent opening of ΔF508 CFTR channels.

Figure 6

(a). Single channel recordings at 37°C of alkaline phosphatase treated ΔF508 CFTR containing combined NBD1 stabilizing mutations without (upper tracing) and with R1070W (middle tracing) as indicated. Lower tracing: single channel recording at 37°C of ΔF508/combo/R1070W with all 15 PKA phosphorylation sites mutated (15SA). X-scale bar below traces is 10s. (b). Tracings for same variants of wild-type rather than ΔF508 CFTR.