Figure 2.

The scheme depicts angiotensin peptides levels using the diameter of the circles to reflect their concentration in plasma (left) and kidney (right) in the WT (upper panels) and ACE2KO mice (lower panels). The enzymes known to cleave the various peptides are shown within the arrows. The peptides formed by ACE2 cleavage are in very low concentrations as opposed to those formed by APA cleavage (blue). Abbreviations: ACE, angiotensin I converting enzyme; ACE2, angiotensin converting enzyme 2; APA, aminopeptidase A; APN, aminopeptidase N; Apx, possible other aminopeptidases.