Table 5.
Clinical markers in echium oil and linseed oil groups before and after 8-weeks treatment1
| Study 1 Echium oil (n = 59) | Study 2 Linseed oil mixture (n = 59) | Treatment effect EO vs. LO P 2 | ||||
|---|---|---|---|---|---|---|
| Total cholesterol (mmol/L) | Day 0 | 5.53 ± 1.25 | 5.27 ± 1.24 | |||
| Day 56 | 5.22 ± 1.17 | *** | 5.08 ± 1.20 | 0.59 | ||
| HDL-C (mmol/L) | Day 0 | 1.45 ± 0.38 | 1.38 ± 0.33 | |||
| Day 56 | 1.37 ± 0.42 | *** | 1.58 ± 0.37 | *** | <0.001 | |
| LDL-C (mmol/L) | Day 0 | 3.33 ± 0.99 | 3.16 ± 1.03 | |||
| Day 56 | 3.03 ± 0.87 | *** | 3.05 ± 0.99 | 0.056 | ||
| LDL-C/HDL-C | Day 0 | 2.43 ± 0.84 | 2.38 ± 0.84 | |||
| Day 56 | 2.36 ± 0.88 | 2.00 ± 0.70 | *** | <0.001 | ||
| Triglycerides (mmol/L) | Day 0 | 1.28 ± 0.70 | 1.22 ± 0.68 | |||
| Day 56 | 1.13 ± 0.59 | *** | 1.12 ± 0.62 | 0.66 | ||
| Oxidized LDL (mmol/L) | Day 0 | 80.1 ± 16.0 | 58.9 ± 17.1 | |||
| Day 56 | 75.8 ± 14.9 | *** | 54.0 ± 17.7 | * | <0.001 | |
| Insulin (mU/L) | Day 0 | 9.07 ± 5.07 | 8.26 ± 5.26 | |||
| Day 56 | 6.25 ± 4.54 | *** | 7.38 ± 3.69 | * | 0.011 |
1Values are means ± SD; adjusted means are not shown. C cholesterol, EO echium oil, LO linseed oil mixture. P values were analyzed using the generalized linear mixed model ANCOVA with sex, age, BMI, baseline value as covariates
2 P values for the treatment effect including only EO and LO groups
*Within one oil treatment, means are significantly different between day 0 and day 56 (repeated measures; ***P ≤ 0.001; *P ≤ 0.05)