Figure 3. Exacerbation of LSECs capillarization in LXRα KO mice induced by CCl₄ chronic administration.

(a) Immunohistochemical staining for CD34 in livers. Scale bar, 50 μm. (b) Statistical analysis of capillary MVD in livers. Data are presented as mean ± SD (**p < 0.01, n = 4, Student’s t-test). (c) TEM and (d) SEM of hepatic sinusoids from WT and LXRα KO mouse treated with CCl₄. White arrows indicate the change of basement membranes in hepatic sinusoids. Scale bar, 1μm. (e) Statistical analysis of porosity. Data are presented as mean ± SD (**p < 0.01, n = 3, Student’s t-test). (f) Ultrastructure of mitochondria (by TEM) in hepatocytes from WT and LXRα KO mouse treated with CCl₄. Abbreviations: m, mitochondrion.