Table 6. TBSS analyses and results comparing Wolfram and control groups after multiple comparison correction.

Measure	Contrast	p < 0.05	White matter regions
FA	All controls > Wolfram	Yes	Parts of corpus callosum body
			Corticospinal tract
			Inferior fronto-occipital fasciculus
			Optic radiations
	Wolfram > All controls	No
RD	Wolfram > All controls	Yes	Middle cerebellar peduncle
			Corticospinal tract
			Interior longitudinal fasciculus
			Inferior fronto-occipital fasciculus
			Optic radiations
			Superior longitudinal fascisulus
	All controls > Wolfram	No
AD	Wolfram > All controls	Yes	Middle cerebellar peduncle
			Inferior fronto-occipital fasciculus
			Interior longitudinal fasciculus
			Anterior limb of internal capsule
	All controls > Wolfram	No

Abbreviations: TBSS, tract-based spatial statistics; FA, fractional anisotropy; RD, radial diffusivity; AD, axial diffusivity.