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. 2016 Feb 18;6:21197. doi: 10.1038/srep21197

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(A) HA inhibits pGC apoptosis. High molecular weight HA (HMW~2 × 10⁶ Da) was added to the culture media. (B) HA promotes the expression of CD44. (C) HA decreased the expression of Caspase-3. (D) HA rescued pGC apoptosis caused by HAS2-siRNA. (E) HA rescue pGC apoptosis caused by miR-26b. (F) Model of the miR-26b-mediated HAS2-HA-CD44-Caspase pathway in the regulation of pGC apoptosis. The average results from three independent experiments are shown. *P < 0.05.