Table 2.
Summary of the surface targeting and oAβ internalization of mutants in SRCR domain of human SR-AI
| Mutants | Mutation position | Surface targeting | oAβ internalization |
|---|---|---|---|
| R351A | β1 | ━ | ━ |
| E360A | β2 | ━ | ━ |
| G361P | β2 | ━ | ━ |
| R362A | β2 | ━ | ━ |
| E364D | β2 | ━ | ━ |
| G369S | Turn | ✚ | ✚ |
| W371A | β3 | ━ | ━ |
| Q385A | α1 | ━ | ━ |
| L391A | Loop | ✚ | ✚ |
| G395A-Q397A | loop-β4 | ✚ | ✚ |
| V399A | β4 | ━ | ━ |
| W413A | β5 | ━ | ━ |
| F418A | loop | ✚ | ✚ |
| C419A | disulfide bond | ━ | ━ |
| F420A | loop | ✚ | ✚ |
| S424A-S425A | loop | ✚ | ✚ |
| R432A | loop | ✚ | ✚ |
| R437A | loop | ✚ | ✚ |
| R432A-R437A | loop | ✚ | ✚ |
| H441R | η2 | ━ | ━ |
| D444A | η2-β6 | ━ | ━ |
Mutation position represents the location of mutated residues in the simulated-structure of SRCR domain
✚, mutants are surface-targeted and do not internalize oAβ
━, mutants are not surface-targeted and do not internalize oAβ