Table 3.
Cox regression analysis of the prognostic factors of the patient survival period.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Age (≤65 years versus >65 years) |
0.83 | 0.45–1.53 | 0.551 | |||
| Sex (male versus female) |
1.17 | 0.64–2.12 | 0.615 | |||
| Previous resection (no versus yes) |
0.73 | 0.37–1.43 | 0.358 | |||
| UICC at first therapy (stage I versus stages II–IV) |
1.20 | 0.96–1.50 | 0.133 | |||
| Lobar spread of disease (unilobar versus bilobar) |
1.47 | 0.78–2.76 | 0.237 | |||
| Extrahepatic metastasis (no versus yes) |
1.55 | 0.78–3.09 | 0.211 | |||
| Tumor load (≤10% versus >10%) |
1.81 | 0.99–3.31 | 0.055 | |||
| Number of lesions (1 versus >1) |
2.44 | 1.27–4.71 | 0.008 | 2.85 | 1.43–5.65 | 0.003 |
| Portal vein thrombosis (no versus yes) |
1.43 | 0.62–3.30 | 0.407 | |||
| Vascular infiltration (no versus yes) |
1.20 | 0.65–2.24 | 0.560 | |||
| Ascites (no versus yes) |
1.49 | 0.66–3.35 | 0.314 | |||
| Liver cirrhosis (no versus yes) |
1.25 | 0.67–2.34 | 0.493 | |||
| Biliary obstruction (no versus yes) |
1.02 | 0.53–1.97 | 0.950 | |||
| ECOG index (0 versus 1–4) |
1.23 | 0.66–2.30 | 0.511 | |||
| CA19–9 (≤39.9 U/mL versus >39.9 U/mL) |
1.93 | 1.01–3.68 | 0.047 | 2.05 | 0.99 – 4.22 | 0.052 |
| CEA (≤3.4 ng/mL versus >3.4 ng/mL) |
2.30 | 1.23–4.31 | 0.009 | 1.89 | 0.97 – 3.72 | 0.025 |
| Objective response (CR + PR versus SD + PD) |
2.43 | 1.28–4.60 | 0.006 | 2.84 | 1.41 – 5.72 | 0.003 |
| Complications (no versus yes) |
1.06 | 0.68–1.67 | 0.796 | |||
| Tumor size (≤50 mm versus >50 mm) |
1.35 | 0.74–2.46 | 0.328 | |||
| Tumor size (≤100 mm versus >100 mm) |
1.22 | 0.60–2.50 | 0.585 | |||
HR, hazard ratio; CI, confidence interval; objective response categories, see Table 2.