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. 2016 Feb 18;17:89. doi: 10.1186/s12891-016-0944-8

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© Mort et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of the structure of aggrecan. Aggrecan is depicted in association with hyaluronan (HA) and link protein (LP) as part of a proteoglycan aggregate. The globular regions of the aggrecan core protein are indicated (G1, G2 and G3) together with the regions of the core protein substituted with keratan sulfate (KS) or chondroitin sulfate (CS1 and CS2) chains. The location of cleavage sites along the core protein for MMPs (M) and aggrecanases (A) are indicated at the bottom of the figure