Fig. 5.—

Synteny between the complete sequence of pLOCK 0919 and the respective DNA fragments of other lactobacilli genomes. The DNA sequence of L. rhamnosus GG is inverted. The respective genome designations are indicated on the right side of each genome line. The predicted ORFs are shown in their respective orientation as boxes with arrows. Conserved genes between pLOCK 0919 and Lactobacillus sp. genomes are depicted in the same color. The local genomic maps are drawn to scale. The direct nucleotide similarity between individual sequences of neighboring genomes is shown as pale pink bands, and inverted similarities are indicated as blue bands. The color shading indicates the level of similarity, with greater saturation of a similarity band indicating more conservation of two ORFs pairs. For better visibility, two IS-reach regions of pLOCK 0919 and L. rhamnosus GG are enlarged in blue circles. The names of homologous ISs from pLOCK 0919 and L. rhamnosus GG are shown in the same colors.