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Transfection of scrambled shRNA inhibits the cell viability. Downregulation of eIF4E by targeted shRNA significantly suppressed the cell viability after 48 and 72 h (*P<0.05 and #P<0.05, vs. the mock group). shRNA, short hairpin RNA; eIF4E, eukaryotic initiation of transcription factor 4E; NC, negative control.
