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Dynamic in vitro release. For free Dex formulation (blue trace), release profile is first-order. For pSiO2-COO-Dex (red trace), a burst release is observed during days 1 to 3. Afterwards, the Dex release was sustained until the end of the 60-day observation period. EC50 = half-maximal effective concentrations in trans-activation assay of three cell lines.31
