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. 2015 Oct 20;12(6):7830–7836. doi: 10.3892/mmr.2015.4455

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-519 inhibited HL60 human AML cell migration predominantly by targeting HuR. (A) A cell migration assay was performed by scratching the cell layer prior to transfection with antago-miR-519 (As-miR-519) or NC. Time-based images were captured from 0–48 h. (B) Flow cytometric analysis of the HL60 cells transfected with HuR-specific siRNA. (C) Cell migration levels were analyzed following HuR inhibition. The data are presented as the mean ± standard error of the mean (n=3) from independent experiments. ^*P<0.05 and ^**P<0.01 vs. NC. AML, acute myeloid leukemia; si, small interfering; NC, negative control; miR, microRNA; HuR, human antigen R.