Figure 12.

(a) Illustration of ligand-receptor interaction catalyzes the formation of nanoscale molecular assemblies. (b) IC₅₀ values of 14 without and with vancomycin ([14]₀/[Van]₀ = 1:1) against HeLa cells for 48 h. (c) At 48 h, the viability of HeLa cells incubated with 14 ([1]₀ = 300 µM) and varying amounts of Van (from 60 µM to 300 µM). (d) IC₅₀ values of (14+Van) against HeLa cells at different conditions. (e) Confocal images showing the time course of fluorescence emission from HeLa cells incubated with 14, Van, and NBD-Van. [14]₀ = 300 µM, [Van]₀ = 294 µM, [NBD-Van]₀ = 6 µM. (f)Cytotoxicity of pre-formed aggregates of 14 against HeLa cells.14 and Van mixed well for 12h, separated the supernatant and aggregates by centrifugation, the obtained aggregates are pre-formed aggregates that is used to treat cells. [14]₀ = [Van]₀ = 500 µM. [64] (Print with the permission from © 2015 American Chemical Society)