Table 1. Data sources used to compile UPR gene sets.

Gene set	Sub-classification			Number of genes	Total number of unique genes
UPR-KEGG-GO	Pathway				265
	KEGG:04141: Protein processing in ER			165
	REACTOME: Unfolded protein response			79
	Gene ontology
	GO:003043: ER-associated ubiquitin-dependent protein catabolic process			38
	GO:0030968: endoplasmic reticulum unfolded protein response			89
	GO:0034976: response to endoplasmic reticulum stress			142
UPR-Interactions	Interactions				281
	ATF4			92
	ATF6			34
	DDIT3			73
	EIF2AK3			13
	ERN1			37
	XBP1			111
UPR-Literature	Publications (High through-put experiments)			1675	2048
	Study	Species	Method
	Labunskyy VM et al. 31	Yeast	Ribosome profiling coupled with NGS	189
	Travers KJ et al. 32	Yeast	DNA microarray	745
	Jonikas MC et al. 33	Yeast	Synthetic genetic array methodology & High-throughput flow cytometry	1262
	Christianson JC et al. 34	Human	Affinity purification, LC-MS/MS, High-throughput Y2H	75
	GeneCards
	GeneCards: ER-Stress			275
	GeneCards: Unfolded Protein Response			325