Table 1.
Genotype frequencies and smoking history in exudative age‐related macular degeneration (AMD) patients and all AMD patients (dry or exudative) compared with control subjects
| Polymorphisms | Controls (n = 119) | Exudative AMD (n = 301) | Pearson chi‐square | Any AMD (n = 373) | Pearson chi‐square |
|---|---|---|---|---|---|
| IL‐8 rs4073 A→T | |||||
| AA | 26 (21.8%) | 45 (15.0%) | p = 0.120 | 61 (16.4%) | p = 0.275 |
| AT | 52 (43.7%) | 161 (53.5%) | 190 (50.9%) | ||
| TT | 41 (34.5%) | 95 (31.6%) | 122 (32.7%) | ||
| NA | 0 | 0 | 0 | ||
| CFH rs1061170 T→C | |||||
| CC | 13 (11.5%) | 109 (36.2%) | p < 0.0001 | 129 (39.2%) | p < 0.0001 |
| CT | 59 (52.2%) | 154 (51.2%) | 162 (49.2%) | ||
| TT | 41 (36.3%) | 38 (12.6%) | 38 (11.6%) | ||
| NA | 6 | 0 | 44 | ||
| ARMS2 rs10490924 G→T | |||||
| TT | 2 (1.8%) | 63 (21.1%) | p < 0.0001 | 70 (21.5%) | p < 0.0001 |
| TG | 42 (36.8%) | 157 (52.7%) | 170 (52.1%) | ||
| GG | 70 (61.4%) | 78 (26.2%) | 86 (26.4%) | ||
| NA | 5 | 3 | 47 | ||
| C3 rs2230199 C→G | |||||
| GG | 4 (3.6%) | 9 (3.0%) | p = 0.437 | 11 (3.4%) | p = 0.422 |
| GC | 27 (24.3%) | 92 (30.8%) | 101 (30.9%) | ||
| CC | 80 (72.1%) | 198 (66.2%) | 215 (65.7%) | ||
| NA | 8 | 2 | 46 | ||
| Tobacco | |||||
| Current smoker | 3 (2.6%) | 50 (17.5%) | p < 0.0001 | 64 (18.0%) | p < 0.0001 |
| Ex‐smoker | 25 (21.9%) | 81 (28.3%) | 95 (26.8%) | ||
| Never smoker | 86 (75.4%) | 155 (54.2%) | 196 (55.2%) | ||
| NA | 5 | 15 | 18 | ||
NA = data not available.