Table 3.
Change in MRI and cognitive indices estimated using a random intercepts and random slopes model fit to the data.
| Parameter | Mean intercept | Mean slope | Slope variance | Residual variance |
|---|---|---|---|---|
| MRI measures | ||||
| Brain volume (ml) | 1295.00 (1279.00, 1312.00) | −8.83 (−10.61, 7.01) | 28.15 (5.63, 54.68) | 182.10 (145.90, 227.40) |
| White matter hyperintensity (%) | 3.72 (3.16, 4.28) | 0.80 (0.67, 0.95) | 0.43 (0.27, 0.65) | 0.12 (0.09, 0.15) |
| MD peak height | 0.015 (0.015, 0.016) | −3.87 × 10−4 (−4.51 × 10−4, −3.24 × 10−4) | 1.55 × 10−4 (8.59 × 10−5, 2.81 × 10−4) | 5.16 × 10−4 (4.62 × 10−4, 5.77 × 10−4) |
| Cognitive indices | ||||
| Executive function | −0.92 (−1.12, −0.73) | 0.0362 (−0.083, 0.0 10) | 0.020 (0.053, 0.0384) | 0.13 (0.10, 0.16) |
| Processing speed | −0.81 (−0.98, −0.64) | 0.014 (−0.053, 0.024) | 0.013 (0.022, 0.026) | 0.092 (0.073, 0.126) |
Abbreviations: MD, mean diffusivity; MRI, magnetic resonance imaging. 95% credible intervals are shown in brackets.