Table 1.

Schedule of assessments.

Year	0									2							4	6						10
Visit	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27
Study information	x
Informed consent	x
Demographya	x								x								x	x						x
Medical history	x								x								x	x						x
Concomitant medication review	x								x								x	x						x
Anthropometryb	x								x									x
Psychic status	x								x								x	x						x
Cognitive status	x								x								x	x						x
Blood pressure	x								x									x
MMSE	x								x								x	x						x
I-FLEX	x								x								x	x						x
GDS20	x								x									x
Neuropsychological exam 1		x								x									x						x
Neuropsychological exam 2			x								x									x						x
EEG				x								x
SPECT					x								x
MRI						x								x							x
ECG							x								x							x
Somatic status							x								x							x
Neurologic status							x								x							x
Blood sample, fasting							x		x									x
Blood sample, non-fasting	x														x							x
LP, fasting															x							x
LP, non-fasting	x
Return visit								x								x							x				x

ECG, electrocardiography; EEG, electroencephalography; GDS20, geriatric depression scale; I-FLEX, investigation of flexibility; LP, lumbar puncture; MMSE, mini mental state examination; SPECT, single-photon emission computed tomography; MRI, magnetic resonance imaging.

^aAge, years of education, sex, marital status, smoking, drinking, and drug habits.

^bHeight, weight, sagittal abdominal diameter, waist circumference, and hip circumference.