Table 1.
Descriptive statistics for demographic, clinical, and imaging variables including DT-MRI and DCE-MRI parameters in normal-appearing white matter and subcortical gray matter.
| Parameter | N | Mean (s.d.) |
|---|---|---|
| Age (years) | 264 | 66.9 (11.8) |
| Sex (% female) | 264 | 42 |
| Stroke subtype (% lacunar) | 264 | 45 |
| Hypertension (%) | 264 | 72 |
| Smokera (%) | 262 | 39 |
| Diabetes (%) | 264 | 11 |
| Pulse pressure (mm Hg) | 264 | 63 (20) |
| Mean arterial pressure (mm Hg) | 264 | 103 (15) |
| Salt intake score | 250 | 2.7 (1.3) |
| Plasma sodium concentration (mmol/L) | 260 | 139 (3) |
| Structural MRI | ||
| %WMH (%) | 264 | 1.5 (1.6) |
| %BTV (%) | 264 | 71 (5) |
| DT-MRI | ||
| MD (10−6 mm2/s) | ||
| GM | 262 | 801 (52) |
| NAWM | 262 | 787 (32) |
| FA | ||
| GM | 262 | 0.234 (0.021) |
| NAWM | 262 | 0.256 (0.022) |
| DCE-MRI | ||
| nAUC (10−3) | ||
| GM | 201 | 16.8 (4.3) |
| NAWM | 201 | 9.9 (3.7) |
Abbreviations: BTV, brain tissue volume; DCE-MRI, dynamic contrast-enhanced MRI; DT-MRI, diffusion tensor MRI; FA, fractional anisotropy; GM, gray matter; MD, mean diffusivity; MRI, magnetic resonance imaging; nAUC, normalized area under curve; NAWM, normal-appearing white matter.
a
Currently smoking or had given up within the previous 12 months.