Table 3.
Multiple linear regression analysis of DT-MRI measurements in normal-appearing white matter and subcortical gray matter.
|
ln(−700 + MDGM [10−6 mm2/s]) |
MDNAWM (10−6 mm2/s) |
FAGM (10−3) |
FANAWM (10−3) |
|||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | |
| PP (mm Hg) | 0.00079 (−0.0018, 0.0033) | 0.54 | 0.16 (−0.021, 0.34) | 0.083 | 0.056 (−0.095, 0.21) | 0.47 | −0.030 (−0.17, 0.11) | 0.68 |
| MAP (mm Hg) | 0.0020 (−0.0013, 0.0052) | 0.24 | −0.14 (−0.38, 0.090) | 0.23 | −0.094 (−0.29, 0.10) | 0.34 | −0.041 (−0.22, 0.14) | 0.66 |
| Hypertension | 0.046 (−0.058, 0.15) | 0.39 | 0.64 (−6.7, 8.0) | 0.86 | −3.7 (−9.8, 2.4) | 0.23 | −2.1 (−7.9, 3.7) | 0.48 |
| Salt intake score | 0.013 (−0.022, 0.048) | 0.46 | 0.54 (−1.9, 3.0) | 0.66 | −3.4 (−5.5, −1.4) | 0.0012 | −1.3 (−3.2, 0.63) | 0.19 |
| Plasma sodium (mmol/L) | −0.0027 (−0.015, 0.010) | 0.68 | −1.2 (−2.1, −0.28) | 0.011 | −0.90 (−1.7, −0.14) | 0.021 | 0.62 (−0.096, 1.3) | 0.090 |
| Smoking | 0.016 (−0.078, 0.11) | 0.74 | 3.8 (−2.9, 10.) | 0.27 | 2.0 (−3.6, 7.6) | 0.48 | −1.5 (−6.8, 3.7) | 0.57 |
| Stroke subtype (cortical = 0, lacunar = 1) | 0.096 (0.0079, 0.18) | 0.033 | 0.60 (−5.7, 6.9) | 0.85 | −9.8 (−15., −4.5) | 0.00029 | −0.047 (−5.0, 4.9) | 0.98 |
| Age (years) | 0.014 (0.0095, 0.018) | <0.0001 | 1.2 (0.89, 1.5) | <0.0001 | 0.088 (−0.18, 0.35) | 0.51 | −0.53 (−0.77, −0.28) | <0.0001 |
| %WMH (%) | 0.15 (0.12, 0.18) | <0.0001 | 4.9 (2.8, 7.0) | <0.0001 | −2.3 (−4.0, −0.56) | 0.0097 | −4.5 (−6.1, −2.9) | <0.0001 |
Abbreviations: CI, confidence interval; DT-MRI, diffusion tensor MRI; MD, mean diffusivity; FA, fractional anisotropy; GM, gray matter; MAP, mean arterial pressure; NAWM, normal-appearing white matter; PP, pulse pressure; WMH, white-matter hyperintensity.