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. 2016 Jan;36(1):55–71. doi: 10.1038/jcbfm.2015.68

Figure 2.

Figure 2.

(a) Main molecular pathways analyzed in subcortical ischemic vascular disease (SIVD). Pie chart of molecular pathways corresponding to those biomarkers reviewed with consistent association with SIVD lesions in more than 1,000 subjects. Portions represent percentage per number of pathways. (b) Functional network of biomarkers reviewed and their predicted partners. Network chart displaying prediction methods (neighborhood, gene fusion, cooccurrence, coexpression, experiments, databases, and textmining) applied to those biomarkers reviewed with consistent association with silent brain infarct (SBI) and white matter hyperintensity (WMH), and their predicted functional partners (underlined in red). Lines represent different link evidences according to different colors, based on databases such as Saccharomyces Genome Database (SGD), Online Mendelian Inheritance in Man (OMIM), FlyBase, and PubMed. Green head arrows: activation; red end lines: inhibition; green lines: coexpression; blue lines: binding; black lines: reaction; gray lines: statistically relevant cooccurrences of genes. Corresponding proteins to gene names of reviewed biomarkers displayed: troponin t (TNNT2), vascular cell adhesion molecule 1 (VCAM1), E-selectin (SELE), interleukin-6 (IL-6), lipoprotein phospholipase A2 (PLA2G7), C- reactive protein (CRP), intercellular adhesion molecule 1 (ICAM1), angiotensin converting enzyme (ACE), von Willebrand factor (vWF), plasminogen activator inhibitor-1 (SERPINE1), and P-selectin (SELP). Corresponding proteins to gene names of predicted partners displayed: urokinase plasminogen activator (PLAU), vitronectin (VTN), tissue plasminogen activator (PLAT), selectin P ligand (SELPLG), integrin beta 2 (ITGB2), integrin alpha L (ITGAL), interleukin-6 signal transducer (IL6ST), interleukin-6 receptor (IL-6R), troponin I type 3 (TNNI3), and troponin C type 1 (TNNC1); STRING database (http://string-db.org/).