Figure 2.

Effect of slow-pressor angiotensin II (ANGII) hypertension on cerebral blood flow (CBF) responses, with and without topical application of amyloid-β (Aβ) to the cerebral cortex. (a) ANGII administration increases mean arterial pressure (MAP). (b and c) The increase in CBF induced by whisker stimulation (b) or acetylcholine (c) is attenuated by ANGII hypertension, but Aβ does not increase the attenuation. (d) The CBF response to adenosine is not affected. *P < 0.05 from saline vehicle; ANOVA and Tukey’s test; n = 5 per group.