Skip to main content
. 2016 Jan;36(1):241–252. doi: 10.1038/jcbfm.2015.79

Figure 4.

Figure 4.

Effect of angiotensin II (ANGII) hypertension on neurovascular responses in Tg2576 mice. (a) Topical ANGII application to the neocortex does not alter mean arterial pressure (MAP). (b and c) Cerebral blood flow (CBF) responses to whisker stimulation (b) or acetylcholine (c) are attenuated in Tg2676 mice, but ANGII does not attenuate the responses further. (d) Slow-pressor ANGII administration increases MAP equally in wild-type (WT) and Tg2576 mice. (e and f) Responses to whisker stimulation (e) or acetylcholine (f) are not attenuated further by ANGII slow-pressor hypertension. *P < 0.05 from WT vehicle; ANOVA and Tukey’s test; n = 5 per group.