Table 1. In silico values of the parameters used in the proposed model.

Parameter	Symbol	In silico value
Diffusion coefficient of the tumor	Mϕ	0.3
Interface width of tumor	λϕ	$2\sqrt{2}$
Diffusion coefficient of the nutrient	Dσ	30
Production rate of nutrient	$V_p^c$	1
Uptake rate of nutrient by tumor	$V_u^T$	6 × 10−3
Uptake rate of nutrient by host tissue	$V_u^H$	6 × 10−4
Necrotic/hypoxic-cell threshold	σn-h	0.2
Hypoxic/viable-cell threshold	σh-v	0.4
TAF condition for highest proliferation	fp	0.3
Mobility of capillaries	Mc	1
Interface width of capillaries	λc	1
Proliferation rate of endothelial cells	Bp	1.401
TEC radius	R	4
Condition 1 for TEC (de)activation	cact	0.9
Condition 2 for TEC (de)activation	fact	0.001
Chemotatic constant	χ	7.28
Dll4 effective distance	δ4	80
Diffusion coefficient of TAF	Df	100
Uptake rate of TAF by capillaries	Bu	6.25

Parameters related to angiogenesis are obtained from [59].