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. 2016 Feb 18;11(2):e0149489. doi: 10.1371/journal.pone.0149489

Fig 1. Stepwise optimization of temperature control during experimental IRI.

Fig 1

Male C57BL/6N mice, 6–8 weeks of age, underwent unilateral IRI under different temperature control settings. (A) Setup A provides minor heat supply during anesthesia and ischemia time. Setup B extends the former setting by providing heat also during incision/ clamping and suturing via a heating plate. Setup C further replaces the temperature supply elements in the phases of anesthesia and ischemia by an egg breeding device. (B) For each of the setups described in (A) rectal temperature was recorded (ORTR) for each individual mouse, that underwent IRI; the data are presented as mean values (black line) and mean ± SD (blue lines). The temperature target range (Tt) is visualized by two red lines (upper and lower limit). (C) ORTR derived body core temperature (Tc) within the margins of Tt [%] calculated from the data presented in (B), with setup A, B and C giving values of 0.7 ± 1.1%, 34.6 ± 28.0% and 99.3 ± 1.5%, respectively. (D) Mean Tc [°C] (including phase I until phase IV) was calculated from the data presented in (B) with setup A, B and C giving values of 34.3 ± 0.8°C, 36.3 ± 0.7°C, 37.8 ± 0.1°C. Data are expressed as mean ± SEM derived from n ≥ 5.