Skip to main content
. 2016 Feb 18;11(2):e0149272. doi: 10.1371/journal.pone.0149272

Fig 10. Proposed Mechanism of MP-induced activation of the endothelium.

Fig 10

Based on the studies presented here we propose the following mechanism for MP-induced activation of the endothelium. 1. MPs interact with the cell surface and induce the 2. EGFR phosphorylation and endocytosis of caveolae 3. EGFR is further phosphorylated followed by 4. phosphorylation of NF-κB subunits p65 and p50. After NF-κB translocation to the nucleus, ICAM-1 transcription is initiated which is dependent on PARP-1 activation and PARP-1 generation.