Table 3.
Distribution of hOGG1 rs1052133 genotypes in Chinese patients with nasopharyngeal carcinoma after stratification by age, sex, or smoking history
| Subgroup | N (case/control) | Number of patients or controlswith genotype (case/control)
|
OR (95% CI) | Adjusted ORa (95% CI) | |
|---|---|---|---|---|---|
| GG | GC + CC | ||||
| Age (years) | |||||
| ≤40 | 136/151 | 39/43 | 97/108 | 1.010 (0.605–1.686) | 0.996 (0.595–1.666) |
| 40 | 352/422 | 112/168 | 240/254 | 0.706 (0.524–0.950) | 0.707 (0.524–0.953) |
| Sex | |||||
| Male | 374/417 | 121/151 | 253/266 | 0.842 (0.627–1.131) | 0.845 (0.628–1.137) |
| Female | 114/156 | 30/60 | 84/96 | 0.571 (0.337–0.968) | 0.574 (0.338–0.975) |
| Smoking history | |||||
| Yes | 166/186 | 53/53 | 113/133 | 0.850 (0.539–1.340) | 0.857 (0.543–1.354) |
| No | 322/387 | 98/158 | 224/229 | 0.635 (0.464–0.866) | 0.634 (0.463–0.868) |
Notes:
a
Calculated by multiple logistic regression after controlling for the other two stratifying factors. For example, the adjusted OR for different age subgroups was adjusted for sex and smoking history.
Abbreviations: hOGG1, human 8-oxoguanine DNA glycosylase 1; OR, odds ratio; CI, confidence interval.