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. 2016 Feb 12;10:619–630. doi: 10.2147/DDDT.S98740

Figure 1.

Figure 1

Effect of fucoidan on liver cytolysis.

Notes: (A) Fucoidan decreased the level of ALT, AST and hydroxyproline content in a dose-dependent manner. Data are expressed as mean ± SD (n=8, *P<0.05 for CCl4 [BDL] versus control, #P<0.05 for CCl4 [BDL] + fucoidan versus CCl4 [BDL], ^P<0.05 for CCl4 [BDL] + fucoidan [25 mg/kg] versus CCl4 [BDL] + fucoidan [10 mg/kg], +P<0.05 for CCl4 [BDL] + fucoidan [50 mg/kg] versus CCl4 [BDL] + fucoidan [25 mg/kg]). (B and C) Fucoidan ameliorated pathological change, showed by H&E and Masson’s trichrome (original magnification: ×200).

Abbreviations: AST, aspartate aminotransferase; SD, standard deviation; CCl4, carbon tetrachloride; BDL, bile duct ligation; H&E, hematoxylin and eosin; ALT, alanine aminotransferase.