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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Cell Rep. 2016 Feb 4;14(6):1308–1316. doi: 10.1016/j.celrep.2016.01.029

Figure 3. Loss of fatty acid oxidation potentiates mitochondrial DNA stress.

Figure 3

(A) Gross interscapular BAT morphology of control and Cpt2A−/− mice after 12 wks of HFDat thermoneutrality.

(B) Hematoxylin and Eosin (H&E) stained BAT from control and Cpt2A−/− mice after 12 wksof HFD at thermoneutrality. Arrows indicate BAT morphology. Scale bar is 100 μM.

(C) Mitochondrial DNA fold suppression of control and Cpt2A−/− BAT at 15°C and 30°C (n=5).

(D) mRNA expression in BAT of interferon stimulated genes in BAT of control and Cpt2A−/− mice injected with vehicle or CL-316243 at thermoneutrality (n=5).

(E) mRNA expression in BAT of interferon stimulated genes in control and Cpt2A−/− mice after 2wks at 15°C, 22°C and 30°C (n=5).

Data are expressed as mean ± SEM. *p<0.05; **p<0.01; ***p<0.001.