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(A). Amino acid sequences of HIV-1 protease variants studied. (B) Ribbon diagrams of HIV-1PR variants showing, as spheres, the locations of drug-pressure selected mutations in PR3, MDR769, V6; and the location of natural polymorphisms in subtype B PR5, subtype C and CRF_01 A/E (molecular model with pdb: 3BVB was used). All primary drug-pressure selected mutations are shown as orange spheres
