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. Author manuscript; available in PMC: 2016 Feb 18.
Published in final edited form as: Phys Chem Chem Phys. 2016 Feb 17;18(8):5819–5831. doi: 10.1039/c5cp04556h

Figure 8.

Figure 8

Bar graphs showing the inhibitor-induced shifts to the closed state, Δc%, with inhibitors for PR natural variants (B, PR5, C and CRF_01A/E), drug-resistant construct (MDR769) and clinical isolates (V6). The relative shift of the closed state is calculated as Δc% = [percentage closed (inhibitor)] – [percentage closed (apo)]. The magenta and red lines correspond to the arbitrary cut-offs to designate weak (<20%), strong (>50%) and moderate (20%< Δc%< 50%) effects of inhibitors on shifting the conformational ensemble.