Table 1.
Parameters of Gaussian-shaped populations used to reconstruct distance profiles for clinical isolate, V6, Ki values of V6 and subtype B constructs and the relative ratio.
| Samples | Curled/Tucked % (population) |
Closed % (population) |
Semi-open % (population) |
Wide-open % (population) |
Ki of V6 a (nM) |
Ki of B a (nM) |
Ratio of Ki V6/B a |
|---|---|---|---|---|---|---|---|
| 25–30Å | 30–35Å | 35–40Å | 40–50Å | ||||
| Apo | 10 | 21 | 61 | 8 | -- | -- | -- |
| CaP2 | 0 | 100 | 0 | 0 | -- | -- | -- |
| DRV | 0 | 100 | 0 | 0 | -- | -- | -- |
| LPV | 17 | 83 | 0 | 0 | -- | 0.11±0.03 | -- |
| TPV | 0 | 100 | 0 | 0 | -- | 0.4±0.04 | -- |
| SQV | 0 | 87 | 13 | 0 | -- | 2.2±0.3 | -- |
| APV | 8 | 72 | 16 | 4 | -- | 0.4±0.1 | -- |
| RTV | 15 | 34 | 51 | 0 | 30±2 | 0.7±0.1 | 42 |
| ATV | 7 | 30 | 63 | 0 | -- | 0.07±0.01 | -- |
| IDV | 10 | 30 | 54 | 6 | 69±8 | 3.1±0.1 | 22 |
| NFV | 14 | 30 | 39 | 17 | 17±3 | 1.2±0.2 | 14 |