Table 1.
Summary of CAN1 sequencing results in strains expressing A3A and A3B
Source of replication stress combined with A3A or A3B expression in ung1Δ strains | ||||
---|---|---|---|---|
None | 50mM HU | rfa1-t33 | tof1Δ | |
Total CanR mutants sequenced | 190 | 122 | 108 | 120 |
CanR mutants with APOBEC signature mutation(s) | 188 | 116 | 106 | 120 |
Frequency of multiple strand-coordinated APOBEC-signature mutations | 0.011 | 0.025 | 0.056 | 0.008 |
Number of mutations present in each CanR mutant with multiple strand-coordinated APOBEC-signature mutations | 2, 2 | 2, 2, 6 | 2, 2, 2, 2, 2, 5, 6 | 2 |