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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: J Pediatr Hematol Oncol. 2016 Mar;38(2):131–138. doi: 10.1097/MPH.0000000000000506

Figure 2. Effects of Glycine-to-Arginine substitution at position 388 of FGFR4 on receptor degradation.

Figure 2

Figure 2

Degradation of V5-tagged Gly388 and Arg388 FGFR4 was examined in SK-N-AS (A) and HEK293T (B) transfected cells. FGFR4 levels were assessed by Western blot at 0, 3, 6, 9, 12, and 24 hours after ligand exposure for each cell line. Images of Ponceau S staining of unrelated areas are shown to indicate equal levels of protein loading. Data represent the mean ± S.E. for 4 (SK-N-AS) and 3 (HEK293T) experiments, *denotes p < 0.05.