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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Neurobiol Dis. 2016 Jan 4;88:29–43. doi: 10.1016/j.nbd.2015.12.019

Figure 7. Increase neuronal excitability in hypoxia and/or IL-1β treated animals.

Figure 7

A) Representative 500 ms recordings of the evoked responses to monopolar stimulations in the layer 4 at 2 V for each treatment in slices prepared from P8–10 mice (top), P13–16 (middle), and P28–30 mice (top). The position of the cortical layers is indicated. The electrodes used for stimulation and calculation of evoked EEs durations are located above the stimulation electrode, marked by the absence of recording, as it was switched off during voltage application. B) Average minimum stimulation voltage needed to initiate an epileptiform response in each treatment (SHAM, dark grey; HYPO, blue; INFL, red; HYPO+INFL, green) in 3 mM KCl- (open bars) or 8 mM KCl-ACSF (filled bars). C) Duration of the evoked responses recorded in layer 2/3 following a 2.5 V stimulation in layer 4 presented as box-and-whisker plots representing the median as a solid line with a box to indicate the interquartile range; the whiskers represent the 10th and 90th percentiles. D) Similar box and whiskers plots representing the median number of barrel columns over which the evoked response was propagating following stimulation in layer 4. Dunns test: **, p<0.01; *, p<0.05.