Table 1.
Number of animals (N) and slices (n) per age group and per experimental condition and average weight. Percentage of slices with spontaneous epileptiform activity is given for experiments performed in 3 mM and 8 mM extracellular K+.
| Age group | Experimental group | Weight (g) | N animals | n Slices | Slices with epileptiform events in 3 mM KCl ACSF | Slices with epileptiform events in 8 mM KCl ACSF | ||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| % | N | % | N | |||||
| P 8–10 | SHAM | 5.42 ± 0.42 | 6 | 7 | 29 | 2/7 | 43 | 3/7 |
| HYPO | 4.52 ± 0.20 | 14 | 18 | 44 | 8/18 | 83 * | 15/18 | |
| INFL | 4.33 ± 0.21 | 8 | 9 | 33 | 3/9 | 89 * | 8/9 | |
| HYPO+INFL | 4.64 ±0.2 | 8 | 12 | 50 | 6/12 | 83 * | 10/12 | |
|
| ||||||||
| P 13–16 | SHAM | 6.06 ± 0.46 | 5 | 7 | 29 | 2/7 | 57 | 4/7 |
| HYPO | 7.48 ± 0.3 | 14 | 21 | 52 | 11/21 | 62 | 13/21 | |
| INFL | 6.83 ± 0.44 | 6 | 8 | 88 | 7/8 | 100 * | 8/8 | |
| HYPO+INFL | 6.93 ± 0.41 | 10 | 17 | 65 | 11/17 | 94 * | 16/17 | |
|
| ||||||||
| P 28–30 | SHAM | 17.45 ± 0.47 | 10 | 10 | 10 | 1/10 | 10 | 1/10 |
| HYPO | 15.45 ± 0.78 | 13 | 17 | 12 | 2/17 | 29 | 5/17 | |
| INFL | 16.1 ± 0.81 | 9 | 11 | 18 | 2/11 | 18 | 2/11 | |
| HYPO+INFL | 14.41 ± 0.8 | 7 | 10 | 10 | 1/10 | 30 | 3/10 | |
Dunns test:
*
p<0.05