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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Cell Rep. 2016 Feb 4;14(6):1435–1447. doi: 10.1016/j.celrep.2016.01.018

Figure 7. Model for ATR Checkpoint Activation Following SIRT2 Deacetylation.

Figure 7

ATRIP deacetylation at K32 by SIRT2 promotes its binding to RPA-ssDNA, driving ATR activation, thus facilitating recovery from replication stress.