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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Drug Dev Res. 2015 Aug 18;76(6):328–342. doi: 10.1002/ddr.21270

Figure 1. miRs regulate RAS-ERK pathway activity by regulation of RAS-GTP.

Figure 1

The schematic shows the organization of the RAS-ERK pathway. miR-206/21 co-targeted repressors of RAS-ERK signaling are indicated in ovals. The GAP protein NF1 is indicated as a likely catalytic partner of SPRED1 [Stowe et al., 2012]. The let-7 miR targets each of the RAS family GTPases including KRAS, HRAS, and NRAS.