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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2015 May 22;99(Pt A):113–128. doi: 10.1016/j.addr.2015.05.009

Figure 1.

Figure 1

Schematic representation of the two step process in suicide gene therapy. In step 1, with the help of a vector the cancer cells are transduced by suicide genes resulting in expression of an enzyme. In step 2, prodrug is administered which can be converted into its cytotoxic form by the enzyme and kill not only the transduced cells but also the neighboring ones.