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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2015 May 22;99(Pt A):113–128. doi: 10.1016/j.addr.2015.05.009

Figure 3.

Figure 3

Deamination of 5-FC by cytosine deaminase (CD). The product, 5-FU is converted to 5-FUMP and eventually 5-FUTP which blocks RNA synthesis. Other byproducts such as 5-FdUMP and 5-FdUTP block DNA synthesis after incorporation into DNA structure.