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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2015 May 22;99(Pt A):113–128. doi: 10.1016/j.addr.2015.05.009

Figure 6.

Figure 6

The two-step process which produces the toxic metabolites, phosphoramide mustard and acrolein from cyclophosphamide. CYP enzyme super family catalyzes the first step whereas the second step is a self-immolative reaction.