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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Adv Drug Deliv Rev. 2015 May 22;99(Pt A):113–128. doi: 10.1016/j.addr.2015.05.009

Table 3.

Sequence differences among wild type HSVTK, SR39 and TK007 mutants. In comparison to wild-type, SR39 has five amino acid mutations at positions 159, 160, 161, 168 and 169, whereas TK007 bears only one mutation at position 168.

Amino Acid Position 159 160 161 168 169
wt-HSVTK L I F A L
SR39 I F L F M
TK007 L I F H L