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. Author manuscript; available in PMC: 2016 Nov 11.
Published in final edited form as: Cell Host Microbe. 2015 Nov 11;18(5):538–548. doi: 10.1016/j.chom.2015.10.008

Figure 7.

Figure 7

Naturally-occurring amino acid variants alter immune recognition of candidate epitopes. Comparison of the magnitude of IFN-γ secretion from cells of individual subjects induced by the ancestral and the variant sequences of individual candidate epitopes. (A) Responses of individuals whose cells responded to the ancestral but not the variant sequence peptide. (B) Responses of individuals whose cells responded to the variant but not the ancestral sequence of each candidate. Each connecting line represents responses of a single subject. Responses were defined as a stimulation index >2, as defined in Methods. See also Table S8.